COA Available
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PT-141
10mg · Lyophilized Powder · Purity ≥99%
PT-141 (Bremelanotide) is a cyclic heptapeptide metabolite of Melanotan II and a non-selective melanocortin receptor agonist, studied as a research tool in MC3R/MC4R pharmacology, hypothalamic neural arousal pathways, and dopaminergic signalling in preclinical CNS models.
$49.99 CAD
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Research Overview
PT-141's structural relationship to Melanotan II — sharing the cyclic α-MSH backbone while possessing a distinct receptor engagement profile — has made it a valuable comparative tool in melanocortin receptor subtype pharmacology research. Its primary activity at MC3R and MC4R in CNS research models is of interest for the study of hypothalamic-dopaminergic signalling axes, where MC4R expression in the paraventricular nucleus has been linked to neural arousal circuit regulation in preclinical behavioural models. Research using PT-141 as a probe has contributed to the broader characterisation of central melanocortin receptor roles in motivation-related signalling pathways. Supplied exclusively for laboratory and research use.
The melanocortin-4 receptor (MC4R) is expressed across multiple hypothalamic nuclei and plays a documented role in energy homeostasis, arousal, and dopaminergic tone in preclinical CNS models. PT-141, as a CNS-penetrant MC4R/MC3R agonist, has been used in animal model research to probe the relationship between central melanocortin signalling and arousal-related neural circuit activity, including the role of oxytocin and dopamine pathway cross-talk downstream of MC4R activation. Unlike peripherally acting melanocortin ligands, PT-141's CNS activity profile makes it a relevant tool for investigating central receptor-mediated signalling phenomena. All outcomes referenced pertain to preclinical models and do not constitute evidence of clinical efficacy or safety in humans.
Specifications
| Compound | PT-141 |
| Format | Lyophilized Powder |
| Size | 10mg |
| Purity (HPLC) | ≥99% |
| Item # | BME-PT1411-A |
| Storage | −20°C, dry, dark |
| Price (CAD) | $49.99 |
COA / Testing
Batch documentation and third-party testing information are available for batch BME-PT1411-A. COA previews appear only when documentation exists for the active batch.
Storage & Handling
PT-141 lyophilized powder should be stored at −20°C in a sealed, light-protected vial to preserve cyclic peptide integrity. Avoid repeated freeze-thaw cycles; prepare single-use aliquots before initial reconstitution. Reconstituted solutions should be stored at 4°C and used within intervals appropriate to the applicable laboratory protocol.
Shipping & Returns
Orders are processed on business days. Packaging is selected to maintain compound integrity in transit. Shipping timelines and return conditions are outlined in full in the Shipping & Returns policy — review before checkout if you have specific requirements. For orders with time-sensitive research schedules, contact support before placing your order.
Research Use Disclaimer
This product is supplied strictly for in-vitro and laboratory research use. It is not a drug, food supplement, or cosmetic and is not approved for human or veterinary clinical applications, diagnostics, or therapeutic use. Researchers are responsible for compliance with all applicable institutional and regulatory requirements in their jurisdiction.
Preparation Reference Guide
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