Dihexa
5mg · Lyophilized Powder · Purity ≥99%
Dihexa is a synthetic angiotensin IV analogue (hexapeptide) studied as a potentiator of the hepatocyte growth factor (HGF)/c-Met signalling axis, with preclinical research examining its role in hippocampal spinogenesis, synaptogenesis, and synaptic plasticity models. Available in oral tablet form.
Subscriptions can be managed from your customer account. Prices in CAD.
Research Overview
Dihexa (N-hexanoic acid-Tyr-Ile-His-Pro-Phe-OH) was developed as a systemically stable hexapeptide capable of high-affinity binding to HGF and potentiation of c-Met receptor phosphorylation at subthreshold HGF concentrations. In hippocampal preclinical models, Dihexa has been investigated for its induction of dendritic spine formation and synaptogenesis at levels comparable to HGF itself, establishing it as a tool for studying neurotrophic signalling mechanisms downstream of the c-Met receptor. This oral tablet formulation provides an alternative administration matrix for research designs requiring non-injectable compound delivery. Supplied exclusively for laboratory and research use.
Research into the HGF/c-Met signalling axis has established c-Met receptor phosphorylation as a key driver of hippocampal synaptogenesis and dendritic spine density. Dihexa functions as a high-affinity HGF-binding hexapeptide that potentiates c-Met activation in the presence of otherwise sub-effective HGF concentrations, providing a tunable tool for exploring dose-dependent aspects of neurotrophic receptor signalling. Preclinical models of dendritic spine formation have demonstrated Dihexa-induced spinogenesis comparable in magnitude to that induced by HGF itself, supporting its utility in synaptic plasticity mechanistic research. All outcomes referenced pertain to preclinical models and do not constitute evidence of clinical efficacy or safety in humans.
Specifications
| Compound | Dihexa |
| Format | Lyophilized Powder |
| Size | 5mg |
| Purity (HPLC) | ≥99% |
| Item # | BME-DIHEXA-A |
| Storage | −20°C, dry, dark |
| Price (CAD) | $249.99 |
COA / Testing
Batch documentation and third-party testing information are available for batch BME-DIHEXA-A. COA previews appear only when documentation exists for the active batch.
Storage & Handling
Dihexa oral tablet formulation should be stored at −20°C in a sealed container, protected from humidity and light. Avoid freeze-thaw cycling of individual units wherever possible. Tablets should be handled under standard laboratory conditions; consult applicable SOPs for stability monitoring of oral peptide formulations.
Shipping & Returns
Orders are processed on business days. Packaging is selected to maintain compound integrity in transit. Shipping timelines and return conditions are outlined in full in the Shipping & Returns policy — review before checkout if you have specific requirements. For orders with time-sensitive research schedules, contact support before placing your order.
Research Use Disclaimer
Research Solution Reference Calculator
Pre-filled with 5mg. Enter your solvent volume and target amount to see concentration and units on a U-100 syringe scale.
For research-use calculations only. Always verify measurements independently — not medical guidance.
Questions before you order?
Browse the FAQ for documentation, storage, and sourcing answers, or contact our support team directly. We aim to respond to all research procurement inquiries within one business day.

