COA Available
Aesthetic In Stock Research Use Only
Snap-8
10mg · Lyophilized Powder · Purity ≥99%
Snap-8 (Acetyl Glutamyl Heptapeptide-1, also known as LEUPHASYL) is a synthetic octapeptide analogue of a SNAP-25 domain, studied as a research tool in SNARE complex biology and synaptic vesicle exocytosis signalling at the neuromuscular junction.
$63.99 CAD
Purchase Options
Subscriptions can be managed from your customer account. Prices in CAD.
Research Overview
Snap-8 replicates a functional domain of SNAP-25 (synaptosomal-associated protein 25), one of the three canonical SNARE complex proteins that govern synaptic vesicle fusion and neurotransmitter release at the neuromuscular junction. As a substrate-competitive analogue, Snap-8 has been employed in cell and tissue models to investigate SNARE complex formation dynamics, vesicle docking regulation, and the downstream consequences of modulated acetylcholine release. Its structural relationship to a known botulinum toxin substrate makes it a relevant probe in neurotransmission research examining SNARE-dependent exocytosis mechanisms. Supplied exclusively for laboratory and research use.
SNARE (soluble NSF attachment protein receptor) complex assembly is fundamental to regulated synaptic vesicle exocytosis, and perturbation of this complex is the primary mechanism by which botulinum toxins affect neurotransmission. Snap-8, as a SNAP-25 C-terminal domain analogue, is studied in research models examining competitive interference with SNARE complex formation — providing a peptide-based tool for probing the kinetics of vesicle docking and fusion processes without the cytotoxic profile of native botulinum toxin substrates. In vitro models have investigated its effects on SNARE protein–protein interaction dynamics and associated exocytotic output. All outcomes referenced pertain to preclinical models and do not constitute evidence of clinical efficacy or safety in humans.
Specifications
| Compound | Snap-8 |
| Format | Lyophilized Powder |
| Size | 10mg |
| Purity (HPLC) | ≥99% |
| Item # | BME-SNAP81-A |
| Storage | −20°C, dry, dark |
| Price (CAD) | $63.99 |
COA / Testing
Batch documentation and third-party testing information are available for batch BME-SNAP81-A. COA previews appear only when documentation exists for the active batch.
Storage & Handling
Snap-8 lyophilized powder should be stored at −20°C in a sealed container, protected from light and moisture. Repeated freeze-thaw cycles should be avoided; prepare aliquots prior to reconstitution to maintain compound integrity throughout the research project. Reconstituted solutions should be kept at 4°C and used within intervals appropriate to laboratory protocols.
Shipping & Returns
Orders are processed on business days. Packaging is selected to maintain compound integrity in transit. Shipping timelines and return conditions are outlined in full in the Shipping & Returns policy — review before checkout if you have specific requirements. For orders with time-sensitive research schedules, contact support before placing your order.
Research Use Disclaimer
This product is supplied strictly for in-vitro and laboratory research use. It is not a drug, food supplement, or cosmetic and is not approved for human or veterinary clinical applications, diagnostics, or therapeutic use. Researchers are responsible for compliance with all applicable institutional and regulatory requirements in their jurisdiction.
Preparation Reference Guide
Research Solution Reference Calculator
Pre-filled with 10mg. Enter your solvent volume and target amount to see concentration and units on a U-100 syringe scale.
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Questions before you order?
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