COA Available
Research In Stock Research Use Only
PNC-27
5mg · Lyophilized Powder · Purity ≥99%
PNC-27 is a synthetic peptide incorporating a segment of the p53 tumour suppressor protein's MDM-2-binding domain fused to a membrane-penetrating sequence, used as a research tool in cancer biology to study selective membranolytic activity in MDM-2-overexpressing tumour cell models.
$142.99 CAD
Purchase Options
Subscriptions can be managed from your customer account. Prices in CAD.
Research Overview
PNC-27 is a chimeric research peptide that combines a segment of the p53 tumour suppressor MDM-2-binding domain with a membrane-penetrating leader sequence, designed to investigate selective membranolytic interactions with cancer cell lines that overexpress the HDM-2 (human MDM-2) receptor on their plasma membranes. In preclinical cell biology research, PNC-27 has been used to study membrane disruption selectivity in transformed versus non-transformed cell populations, making it a tool for probing MDM-2 surface expression and cancer cell membrane biology. BME Health supplies PNC-27 as a lyophilized high-purity research peptide in 5mg and 10mg formats. Supplied exclusively for laboratory and research use.
Preclinical cell-based studies have employed PNC-27 to investigate its selective interaction with HDM-2 receptor complexes expressed on transformed cancer cell membranes, with research examining membranolytic activity, membrane integrity disruption, and differential effects on cancerous versus normal cell preparations. The p53 MDM-2-binding domain incorporated in PNC-27's sequence provides a research tool for exploring p53-related oncology pathways and membrane receptor biology simultaneously. Studies have used PNC-27 as a pharmacological probe in oncology and cell membrane biology research contexts. All outcomes referenced do not constitute evidence of clinical efficacy or safety in humans.
Specifications
| Compound | PNC-27 |
| Format | Lyophilized Powder |
| Size | 5mg |
| Purity (HPLC) | ≥99% |
| Item # | BME-PNC275-A |
| Storage | −20°C, dry, dark |
| Price (CAD) | $142.99 |
COA / Testing
Batch documentation and third-party testing information are available for batch BME-PNC275-A. COA previews appear only when documentation exists for the active batch.
Storage & Handling
Store lyophilized PNC-27 at −20°C in a sealed, dry container protected from light. As a chimeric peptide with a membrane-penetrating sequence, PNC-27 may exhibit surface-adsorptive properties; prepare reconstituted solutions in low-protein-binding labware and use promptly to avoid activity loss. Avoid repeated freeze-thaw cycles.
Shipping & Returns
Orders are processed on business days. Packaging is selected to maintain compound integrity in transit. Shipping timelines and return conditions are outlined in full in the Shipping & Returns policy — review before checkout if you have specific requirements. For orders with time-sensitive research schedules, contact support before placing your order.
Research Use Disclaimer
This product is supplied strictly for in-vitro and laboratory research use. It is not a drug, food supplement, or cosmetic and is not approved for human or veterinary clinical applications, diagnostics, or therapeutic use. Researchers are responsible for compliance with all applicable institutional and regulatory requirements in their jurisdiction.
Preparation Reference Guide
Research Solution Reference Calculator
Pre-filled with 5mg. Enter your solvent volume and target amount to see concentration and units on a U-100 syringe scale.
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For research-use calculations only. Always verify measurements independently — not medical guidance.
Questions before you order?
Browse the FAQ for documentation, storage, and sourcing answers, or contact our support team directly. We aim to respond to all research procurement inquiries within one business day.
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