COA Available
Performance In Stock Research Use Only
IGF-1 LR3
1mg · Lyophilized Powder · Purity ≥99%
IGF-1 LR3 is a synthetic analogue of human IGF-1 engineered with a 13-amino-acid N-terminal extension and an Arg→Gly substitution at position 3 that substantially reduces IGF-binding protein (IGFBP) affinity. This structural modification extends plasma half-life to approximately 20–30 hours and confers approximately 3× greater potency than native IGF-1 in cell-based assays, making it a well-characterised tool compound for IGF-1 receptor signalling research.
$119.99 CAD
Purchase Options
Subscriptions can be managed from your customer account. Prices in CAD.
Research Overview
IGF-1 LR3 retains full agonist activity at the IGF-1 receptor and activates downstream PI3K/Akt and Raf/MEK/ERK signalling cascades as demonstrated in cell culture studies. Its reduced IGFBP binding allows researchers to study direct receptor-mediated effects with minimal confounding from endogenous binding protein sequestration. Each vial is manufactured to ≥98% purity by HPLC and is supplied with a certificate of analysis (COA). Supplied exclusively for laboratory and research use.
Preclinical research utilising IGF-1 LR3 has examined receptor occupancy kinetics, intracellular signalling pathway activation, and cell proliferation responses in vitro. Studies comparing native IGF-1 to LR3 variants have used this analogue to isolate receptor-dependent effects from IGFBP-mediated modulation. The extended half-life profile makes it a useful reference compound for time-course signalling experiments in cell and tissue models. All outcomes referenced pertain to preclinical models and do not constitute evidence of clinical efficacy or safety in humans.
Specifications
| Compound | IGF-1 LR3 |
| Format | Lyophilized Powder |
| Size | 1mg |
| Purity (HPLC) | ≥99% |
| Item # | BME-IGF1LR-A |
| Storage | −20°C, dry, dark |
| Price (CAD) | $119.99 |
COA / Testing
Batch documentation and third-party testing information are available for batch BME-IGF1LR-A. COA previews appear only when documentation exists for the active batch.
Storage & Handling
Store lyophilised IGF-1 LR3 at −20°C in a dry environment, protected from light. Avoid repeated freeze-thaw cycles, as these degrade peptide integrity and reduce biological activity in assay systems. Once reconstituted, aliquot immediately and store at −80°C for extended use; consume reconstituted material within the timeframe specified in the COA documentation.
Shipping & Returns
Orders are processed on business days. Packaging is selected to maintain compound integrity in transit. Shipping timelines and return conditions are outlined in full in the Shipping & Returns policy — review before checkout if you have specific requirements. For orders with time-sensitive research schedules, contact support before placing your order.
Research Use Disclaimer
This product is supplied strictly for in-vitro and laboratory research use. It is not a drug, food supplement, or cosmetic and is not approved for human or veterinary clinical applications, diagnostics, or therapeutic use. Researchers are responsible for compliance with all applicable institutional and regulatory requirements in their jurisdiction.
Preparation Reference Guide
Research Solution Reference Calculator
Pre-filled with 1mg. Enter your solvent volume and target amount to see concentration and units on a U-100 syringe scale.
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For research-use calculations only. Always verify measurements independently — not medical guidance.
Questions before you order?
Browse the FAQ for documentation, storage, and sourcing answers, or contact our support team directly. We aim to respond to all research procurement inquiries within one business day.
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