COA Available
Performance In Stock Research Use Only
CJC-1295 (no DAC)
5mg · Lyophilized Powder · Purity ≥99%
CJC-1295 without DAC — also designated Modified GRF(1-29) or Mod GRF 1-29 — is a 29-amino-acid GHRH analogue incorporating four amino acid substitutions that increase receptor binding affinity and enzymatic stability relative to native GHRH(1-29)/sermorelin. Without a Drug Affinity Complex, it retains a shorter half-life and produces more discrete, pulsatile GH release patterns in preclinical models.
$59.99 CAD
Purchase Options
Subscriptions can be managed from your customer account. Prices in CAD.
Research Overview
The four substitution positions in CJC-1295 without DAC confer resistance to dipeptidylpeptidase IV (DPP-IV) and other plasma proteases while preserving full GHRH receptor agonist activity, making it a useful tool for studying GHRH receptor pharmacology with improved in-vitro and ex-vivo stability compared to the native peptide. Its shorter half-life relative to the DAC variant supports research designs requiring pulsatile or time-delimited GHRH receptor stimulation. BME Health supplies this compound at ≥98% purity by HPLC. Supplied exclusively for laboratory and research use.
Preclinical studies have used Modified GRF(1-29)/CJC-1295 without DAC to probe GHRH receptor activation kinetics, cAMP accumulation, and downstream GH release in somatotroph cell models. Comparative studies have leveraged the compound alongside native GHRH(1-29) to isolate the contribution of individual substitution sites to receptor affinity and protease resistance. Its half-life profile in animal models makes it a reference standard for short-duration GHRH axis signalling experiments. All outcomes referenced pertain to preclinical models and do not constitute evidence of clinical efficacy or safety in humans.
Specifications
| Compound | CJC-1295 (no DAC) |
| Format | Lyophilized Powder |
| Size | 5mg |
| Purity (HPLC) | ≥99% |
| Item # | BME-CJC129-A |
| Storage | −20°C, dry, dark |
| Price (CAD) | $59.99 |
COA / Testing
Batch documentation and third-party testing information are available for batch BME-CJC129-A. COA previews appear only when documentation exists for the active batch.
Storage & Handling
Store lyophilised CJC-1295 without DAC at −20°C in its original sealed vial, protected from moisture and light. Avoid repeated freeze-thaw cycles, which degrade the peptide backbone and reduce reproducibility in receptor binding assays. Reconstituted solutions should be aliquoted and stored at −80°C; consult the lot-specific COA for validated stability parameters.
Shipping & Returns
Orders are processed on business days. Packaging is selected to maintain compound integrity in transit. Shipping timelines and return conditions are outlined in full in the Shipping & Returns policy — review before checkout if you have specific requirements. For orders with time-sensitive research schedules, contact support before placing your order.
Research Use Disclaimer
This product is supplied strictly for in-vitro and laboratory research use. It is not a drug, food supplement, or cosmetic and is not approved for human or veterinary clinical applications, diagnostics, or therapeutic use. Researchers are responsible for compliance with all applicable institutional and regulatory requirements in their jurisdiction.
Preparation Reference Guide
Research Solution Reference Calculator
Pre-filled with 5mg. Enter your solvent volume and target amount to see concentration and units on a U-100 syringe scale.
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For research-use calculations only. Always verify measurements independently — not medical guidance.
Questions before you order?
Browse the FAQ for documentation, storage, and sourcing answers, or contact our support team directly. We aim to respond to all research procurement inquiries within one business day.
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